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Lo/Ovral contains a combination of ethinyl estradiol and norgestrel. Ethinyl estradiol and norgestrel are female hormones that prevent ovulation (the release of an egg from an ovary). Lo/Ovral-28 also causes changes in your cervical mucus and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus.